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In large obesity trials using full doses, once-weekly semaglutide and tirzepatide led to substantial average weight loss and improved metabolic markers in adults with obesity.[13] For example, the STEP 1 trial of once-weekly semaglutide in adults with overweight or obesity and the SURMOUNT-1 tirzepatide obesity trial both showed strong weight-loss effects when combined with lifestyle changes

DB enhances insulin release through mechanisms involving KATP channels, bitter taste receptor signaling, and intraislet GLP-1 secretion

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More time and clinical studies are needed to determine whatever long-term health benefits and cost avoidance result from prescribing and covering these drugs for weight loss

The model wasnt wrong, but was incomplete

The brand names are Mounjaro for diabetes and Zepbound for weight management